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Publications

Our research is regularly featured in leading scientific journals across the fields of metabolism, pharmacology, cannabinoid science, and translational medicine. These publications reflect our lab’s commitment to advancing fundamental knowledge and developing innovative therapeutic strategies with real-world impact.

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Activation of the Nlrp3 Inflammasome in Infiltrating Macrophages by Endocannabinoids Mediates Beta Cell Loss in Type 2 Diabetes

​Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, Tam J, Han T, Mukhopadhyay B, Ju C, Kunos G

Nat Med 19:1132-1140.
2013

Featured in Nature Review in Endocrinology (2013) 9:626.

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Hepatic Cannabinoid Receptor 1 Mediates Diet-induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice

Liu J, Zhou L, Xiong K, Godlewski G, Mukhoadhyay B, Tam J, Yin S, Gao P, Shan X, Pickel J, Bataller R, O’Hare J, Scherer T, Buettner C, Kunos G

Gastroenterology 142:1218-1228.
2012
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Mitochondrial Biogenesis and Increased Uncoupling Protein 1 in Brown Adipose Tissue of Mice Fed a Ketone Ester Diet

Srivastava S, Kashiwaya Y, King MT, Baxa U, Tam J, Niu G, Chen X, Clarke K, Veech RL

FASEB J 26:2351-2362.
2012
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Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

Tam J, Cinar R, Liu J, Godlewski G, Wesley D, Jourdan T, Szanda G, Mukhopadhyay B, Chedester L, Liow JS, Innis RB, Cheng K, Rice KC, Deschamps JR, Chorvat RJ, McElroy JF, Kunos G

Cell Metab 16:167-179.
2012

Appeared on the August 2012 cover page of Cell Metabolism

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The Case for Peripheral CB1 Receptor Blockade in the Treatment of Visceral Obesity and its Cardiometabolic Complications

Kunos G, Tam J

Br J Pharmacol 163: 1423-1431.
2011
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Hyperactivation of Anandamide Synthesis and Regulation of Cell-cycle Progression via Cannabinoid Type 1 (CB1) Receptors in the Regenerating Liver

Mukhopadhyay B, Cinar R, Yin S, Liu J, Tam J, Godlewski G, Harvey-White J, Mordi I, Cravatt BF, Lotersztajn S, Gao B, Yuan Q, Schuebel K, Goldman D, Kunos G

Proc Natl Acad Sci USA 108:6323-6328.
2011

Highlighted in Proc Natl Acad Sci USA (2011) 108: 6339-40.

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Endocannabinoids in Liver Disease

Tam J, Liu J, Mukhopadhyay B, Cinar R, Godlewski G, Kunos G

Hepatology 53:346-355.
2011
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Inhibitor of Fatty Acid Amide Hydrolase Normalizes Cardiovascular Function in Hypertension without Adverse Metabolic Effects

Godlewski G, Alapafuja SO, Bátkai S, Nikas SP, Cinar R, Offertáler L, Osei-Hyiaman D, Liu J, Mukhopadhyay B, Harvey-White J, Tam J, Pacak K, Cravatt BF, Makriyannis A,  Kunos G

Chem Biol 17:1256–1266.
2010
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Peripheral CB1 Cannabinoid Receptor Blockade Improves Cardiometabolic Risk in Mouse Models of Obesity

Tam J, Vemuri VK, Liu J, Bátkai C, Mukhopadhyay B, Godlewski G, Osei-Hyiaman D, Ohnuma S, Ambudkar SV, Makriyannis A, Kunos G

J Clin Invest 120:2953–2966.
2010

Highlighted in J Clin Invest (2010) 120:2646-8.

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Oleoyl-serine, an Endogenous N-acyl Amide Modulates Bone Remodeling and Mass

Smoum R, Bar A, Tan B, Milman G, Attar-Namdar M, Ofek O, Stuart JM, Bajayo A, Tam J, Kram V, O’Dell D, Walker MJ, Bradshaw HB, Bab I, Mechoulam R

Proc Natl Acad Sci USA 107:17710-17715.
2010

NO RESULTS

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