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Publications

Our research is regularly featured in leading scientific journals across the fields of metabolism, pharmacology, cannabinoid science, and translational medicine. These publications reflect our lab’s commitment to advancing fundamental knowledge and developing innovative therapeutic strategies with real-world impact.

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Role of the Endocannabinoid System in Hepatic Lipogenesis

Tam J

Hepatic De Novo Lipogenesis and Regulation of Metabolism. Springer, Cham.
2015
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Hepatic Cannabinoid-1 Receptors Mediate Diet-induced Insulin Resistance by Increasing de novo Synthesis of Long-chain Ceramides

Cinar R, Godlewski G, Liu J, Tam J, Jourdan T, Mukhopadhyay B, Harvey-White J, Kunos G

Hepatology 59:143-153.
2014
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Role of Adiponectin in the Metabolic Effects of Cannabinoid Receptor-1 Blockade in Mice with Diet-Induced Obesity

Tam J, Godlewski G, Earley BJ, Zhou L, Jourdan T, Szanda G, Cinar R, Kunos G

Am J Physiol Endocrinol Metab 306:E457-468.
2014
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Overactive Cannabinoid 1 Receptor in Podocytes Drives Type-2 Diabetic Nephropathy

Jourdan T, Szanda G, Rosenberg AZ, Tam J, Earley B, Godlewski G, Cinar R, Liu Z, Liu J, Ju C, Pacher P, Kunos G

Proc Natl Acad Sci USA 111:E5420-5428.
2014
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Glucocorticoid Receptor Dimerization is Required for Proper Recovery of LPS-induced Inflammation, Sickness Behavior and Metabolism in Mice

Silverman MN, Mukhopadhyay P, Belyavskaya E, Tonelli LH, Revenis BD, Doran JH, Ballard BE, Tam J, Pacher P, Sternberg EM

Mol Psychiatry 18:1006-1017.
2013
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Activation of the Nlrp3 Inflammasome in Infiltrating Macrophages by Endocannabinoids Mediates Beta Cell Loss in Type 2 Diabetes

​Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J, Tam J, Han T, Mukhopadhyay B, Ju C, Kunos G

Nat Med 19:1132-1140.
2013

Featured in Nature Review in Endocrinology (2013) 9:626.

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Hepatic Cannabinoid Receptor 1 Mediates Diet-induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice

Liu J, Zhou L, Xiong K, Godlewski G, Mukhoadhyay B, Tam J, Yin S, Gao P, Shan X, Pickel J, Bataller R, O’Hare J, Scherer T, Buettner C, Kunos G

Gastroenterology 142:1218-1228.
2012
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Mitochondrial Biogenesis and Increased Uncoupling Protein 1 in Brown Adipose Tissue of Mice Fed a Ketone Ester Diet

Srivastava S, Kashiwaya Y, King MT, Baxa U, Tam J, Niu G, Chen X, Clarke K, Veech RL

FASEB J 26:2351-2362.
2012
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Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

Tam J, Cinar R, Liu J, Godlewski G, Wesley D, Jourdan T, Szanda G, Mukhopadhyay B, Chedester L, Liow JS, Innis RB, Cheng K, Rice KC, Deschamps JR, Chorvat RJ, McElroy JF, Kunos G

Cell Metab 16:167-179.
2012

Appeared on the August 2012 cover page of Cell Metabolism

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The Case for Peripheral CB1 Receptor Blockade in the Treatment of Visceral Obesity and its Cardiometabolic Complications

Kunos G, Tam J

Br J Pharmacol 163: 1423-1431.
2011

NO RESULTS

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